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Πλοήγηση ανά Συγγραφέα "Ntougkos, E."

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    • Rationally Designed Less Toxic SPD-304 Analogs and Preliminary Evaluation of Their TNF Inhibitory Effects 

      Alexiou, P.; Papakyriakou, A.; Ntougkos, E.; Papaneophytou, C. P.; Liepouri, F.; Mettou, A.; Katsoulis, I.; Maranti, A.; Tsiliouka, K.; Strongilos, A.; Chaitidou, S.; Douni, E.; Kontopidis, G.; Kollias, G.; Couladouros, E.; Eliopoulos, E. (2014)
      SPD-304 was discovered as a promising tumor necrosis factor alpha (TNF) antagonist that promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. However, SPD-304 contains a potentially ...

    • Synthesis and biological evaluation of potential small molecule inhibitors of tumor necrosis factor 

      Papaneophytou, C.; Alexiou, P.; Papakyriakou, A.; Ntougkos, E.; Tsiliouka, K.; Maranti, A.; Liepouri, F.; Strongilos, A.; Mettou, A.; Couladouros, E.; Eliopoulos, E.; Douni, E.; Kollias, G.; Kontopidis, G. (2015)
      Inhibition of tumor necrosis factor (TNF) production or function by small molecules has become a major focus in the pharmaceutical industry for the treatment of rheumatoid arthritis. In this study, a series of 39 novel ...